Potential Reduction Scenarios of Diabetes Drugs

Due to Blood sugar improvement with Supplements

Here are some additional scenarios illustrating potential medication reductions in diabetes management, along with specific numbers, assuming consistent blood sugar control within target range:

Oral Medications

• Sulfonylureas (e.g., glipizide, glimepiride):
  • Reduction: Decrease dose by 25-50% every 2-4 weeks
  • Example: If taking glipizide 5 mg twice daily, reduce to 2.5 mg twice daily for 2-4 weeks, then reassess blood sugar control
• DPP-4 inhibitors (e.g., sitagliptin, saxagliptin):
  • Reduction: May consider discontinuing if blood sugar control is excellent and other medications are sufficient
  • Example: If taking sitagliptin 100 mg daily, discuss with doctor about stopping it if A1C and blood sugar levels are consistently within target
• SGLT2 inhibitors (e.g., empagliflozin, canagliflozin):
  • Reduction: Decrease dose by half every 2-4 weeks, or consider discontinuing if other medications are sufficient
  • Example: If taking empagliflozin 10 mg daily, reduce to 5 mg daily for 2-4 weeks, then reassess

Insulin

• Basal Insulin (e.g., glargine, detemir):
  • Reduction: Decrease dose by 10% every 1-2 weeks
  • Example: If taking Lantus 20 units at bedtime, reduce to 18 units for 1-2 weeks, then reassess
• Bolus Insulin (e.g., lispro, aspart):
  • Reduction: decrease pre-meal dose by 1-2 units
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